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Product Details
15279-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DHRS4 Fusion Protein Ag7398 (1-278 aa encoded by BC003019)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: MHKAGLLGL CARAWNSVRM ASSGMTRRDP LANKVALVTA STDGIGFAIA RRLAQDGAHV VVSSRKQQNV DQAVATLQGE GLSVTGTVCH VGKAEDRERL VATAVKLHGG IDILVSNAAV NPFFGSIMDV TEEVWDKTLD INVKAPALMT KAVVPEMEKR GGGSVVIVSS IAAFSPSPGF SPYNVSKTAL LGLTKTLAIE LAPRNIRVNC LAPGLIKTSF SRMLWMDKEK EESMKETLRI RRLGEPEDCA GIVSFLCSED ASYITGETVV VGGGTPSRL (1-278 aa encoded by BC003019 )
Target Information
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: carbonyl reductase; CR; DCR-AKL; dehydrogenase/reductase (SDR family) member 4 like 2A; Dehydrogenase/reductase SDR family member 4; NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; NRDR; Peroxisomal short-chain alcohol dehydrogenase; PH PSCD; PHCR; Protein SDR25C2; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; Short-chain dehydrogenase/reductase family member 4
Gene Aliases: AI043103; AI790593; CR; D14Ucla2; DHRS4; mouNRDR; NDRD; NRDR; PHCR; PSCD; RRD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2; UNQ851/PRO1800
UniProt ID: (Human) D3YTB8, (Rat) Q8VID1, (Mouse) Q99LB2
Entrez Gene ID: (Human) 10901, (Rat) 266686, (Mouse) 28200
Molecular Function:
dehydrogenase
3-keto sterol reductase activity
carbonyl reductase (NADPH) activity
receptor binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
alcohol dehydrogenase [NAD(P)+] activity
NADP-retinol dehydrogenase activity
retinal dehydrogenase activity
oxidoreductase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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