FIGURE: 1 / 10
Immunogen sequence: MHKAGLLGL CARAWNSVRM ASSGMTRRDP LANKVALVTA STDGIGFAIA RRLAQDGAHV VVSSRKQQNV DQAVATLQGE GLSVTGTVCH VGKAEDRERL VATAVKLHGG IDILVSNAAV NPFFGSIMDV TEEVWDKTLD INVKAPALMT KAVVPEMEKR GGGSVVIVSS IAAFSPSPGF SPYNVSKTAL LGLTKTLAIE LAPRNIRVNC LAPGLIKTSF SRMLWMDKEK EESMKETLRI RRLGEPEDCA GIVSFLCSED ASYITGETVV VGGGTPSRL (1-278 aa encoded by BC003019 )
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: carbonyl reductase; CR; DCR-AKL; dehydrogenase/reductase (SDR family) member 4 like 2A; Dehydrogenase/reductase SDR family member 4; NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; NRDR; Peroxisomal short-chain alcohol dehydrogenase; PH PSCD; PHCR; Protein SDR25C2; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; Short-chain dehydrogenase/reductase family member 4
Gene Aliases: AI043103; AI790593; CR; D14Ucla2; DHRS4; mouNRDR; NDRD; NRDR; PHCR; PSCD; RRD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2; UNQ851/PRO1800
Molecular Function: dehydrogenase