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Product Details
13159-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DHX36 Fusion Protein Ag3799 (1-385 aa encoded by BC036035)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSYDYHQNW GRDGGPRSSG GGYGGGPAGG HGGNRGSGGG GGGGGGGRGG RGRHPGHLKG REIGMWYAKK QGQKNKEAER QERAVVHMDE RREEQIVQLL NSVQAKNDKE SEAQISWFAP EDHGYGTEVS TKNTPCSENK LDIQEKKLIN QEKKMFRIRN RSYIDRDSEY LLQENEPDGT LDQKLLEDLQ KKKNDLRYIE MQHFREKLPS YGMQKELVNL IDNHQVTVIS GETGCGKTTQ VTQFILDNYI ERGKGSACRI VCTQPRRISA ISVAERVAAE RAESCGSGNS TGYQIRLQSR LPRKQGSILY CTTGIILQWL QSDPYLSSVS HIVLDEIHER NLQSDVLMTV VKDLLNFRSD LKVILMSATL NAEKFSEYFG NCPMIH (1-385 aa encoded by B C036035)
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. DHX36 (DEAH box protein 36), also known as MLE-like protein 1 and RNA helicase associated with AU-rich element ARE (RHAU), belongs to RNA helicase of the DEAH family and may function in sex development and spermatogenesis. It is expressed in testis and is evolutionary conserved with true orthologs in almost all animal species. DHX36 plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. DHX36 is required for early embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Asp-Glu-Ala-His; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DEAH-box protein 36; G4 resolvase-1; G4-resolvase 1; G4-resolvase-1; G4R1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein
Gene Aliases: 2810407E23Rik; AI452301; AU022184; DDX36; DHX36; G4R1; KIAA1488; mKIAA1488; MLEL1; RHAU
UniProt ID: (Human) Q9H2U1, (Rat) D4A2Z8, (Mouse) Q8VHK9
Entrez Gene ID: (Human) 170506, (Rat) 310461, (Mouse) 72162
core promoter binding
G-quadruplex RNA binding
double-stranded RNA binding
ATP-dependent RNA helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
histone deacetylase binding
transcription regulatory region DNA binding
poly(A) RNA binding
G-quadruplex DNA binding
nucleotide binding
nucleic acid binding
DNA binding
RNA binding
helicase activity
ATP-dependent helicase activity
hydrolase activity
RNA helicase
ossification
transcription, DNA-templated
RNA processing
response to virus
RNA secondary structure unwinding
positive regulation of telomere maintenance
positive regulation of type I interferon production
response to exogenous dsRNA
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
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