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Proteintech

DHX36 Polyclonal Antibody

14 References
View all (11) DHX36 antibodies

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DHX36 Polyclonal Antibody

Product Details

13159-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DHX36 Fusion Protein Ag3799 (1-385 aa encoded by BC036035)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSYDYHQNW GRDGGPRSSG GGYGGGPAGG HGGNRGSGGG GGGGGGGRGG RGRHPGHLKG REIGMWYAKK QGQKNKEAER QERAVVHMDE RREEQIVQLL NSVQAKNDKE SEAQISWFAP EDHGYGTEVS TKNTPCSENK LDIQEKKLIN QEKKMFRIRN RSYIDRDSEY LLQENEPDGT LDQKLLEDLQ KKKNDLRYIE MQHFREKLPS YGMQKELVNL IDNHQVTVIS GETGCGKTTQ VTQFILDNYI ERGKGSACRI VCTQPRRISA ISVAERVAAE RAESCGSGNS TGYQIRLQSR LPRKQGSILY CTTGIILQWL QSDPYLSSVS HIVLDEIHER NLQSDVLMTV VKDLLNFRSD LKVILMSATL NAEKFSEYFG NCPMIH (1-385 aa encoded by B C036035)

Target Information

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. DHX36 (DEAH box protein 36), also known as MLE-like protein 1 and RNA helicase associated with AU-rich element ARE (RHAU), belongs to RNA helicase of the DEAH family and may function in sex development and spermatogenesis. It is expressed in testis and is evolutionary conserved with true orthologs in almost all animal species. DHX36 plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. DHX36 is required for early embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Asp-Glu-Ala-His; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DEAH-box protein 36; G4 resolvase-1; G4-resolvase-1; G4R1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein; unnamed protein product

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Gene Aliases: 2810407E23Rik; AI452301; AU022184; DDX36; DHX36; G4R1; KIAA1488; mKIAA1488; MLEL1; RHAU

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UniProt ID: (Human) Q9H2U1, (Rat) D4A2Z8, (Mouse) Q8VHK9

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Entrez Gene ID: (Human) 170506, (Rat) 310461, (Mouse) 72162

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Function(s)
nucleotide binding magnesium ion binding transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding G-quadruplex RNA binding nucleic acid binding DNA binding DNA helicase activity single-stranded DNA binding RNA binding RNA helicase activity double-stranded RNA binding mRNA 3'-UTR binding helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity ATPase activity mRNA 3'-UTR AU-rich region binding histone deacetylase binding metal ion binding mRNA 5'-UTR binding G-quadruplex DNA binding telomerase RNA binding pre-miRNA binding catalytic activity, acting on a nucleic acid core promoter binding ATP-dependent RNA helicase activity transcription regulatory region DNA binding poly(A) RNA binding ATP-dependent helicase activity RNA helicase
Process(es)
ossification immune system process positive regulation of myeloid dendritic cell cytokine production regulation of transcription from RNA polymerase III promoter regulation of translation spermatogenesis response to virus positive regulation of gene expression negative regulation of translation cell differentiation positive regulation of mRNA 3'-end processing positive regulation of telomere maintenance positive regulation of interferon-alpha production cellular response to heat cellular response to UV positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA regulation of mRNA stability innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development defense response to virus positive regulation of cardioblast differentiation positive regulation of transcription initiation from RNA polymerase II promoter positive regulation of dendritic spine morphogenesis 3'-UTR-mediated mRNA destabilization telomerase RNA stabilization positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of hematopoietic progenitor cell differentiation cellular response to arsenite ion positive regulation of telomere maintenance via telomere lengthening positive regulation of intracellular mRNA localization positive regulation of cytoplasmic translation RNA processing RNA secondary structure unwinding transcription, DNA-templated regulation of transcription, DNA-templated
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