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Proteintech
DHX36 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13159-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Monkey,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DHX36 Fusion Protein Ag3799 (1-385 aa encoded by BC036035)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSYDYHQNW GRDGGPRSSG GGYGGGPAGG HGGNRGSGGG GGGGGGGRGG RGRHPGHLKG REIGMWYAKK QGQKNKEAER QERAVVHMDE RREEQIVQLL NSVQAKNDKE SEAQISWFAP EDHGYGTEVS TKNTPCSENK LDIQEKKLIN QEKKMFRIRN RSYIDRDSEY LLQENEPDGT LDQKLLEDLQ KKKNDLRYIE MQHFREKLPS YGMQKELVNL IDNHQVTVIS GETGCGKTTQ VTQFILDNYI ERGKGSACRI VCTQPRRISA ISVAERVAAE RAESCGSGNS TGYQIRLQSR LPRKQGSILY CTTGIILQWL QSDPYLSSVS HIVLDEIHER NLQSDVLMTV VKDLLNFRSD LKVILMSATL NAEKFSEYFG NCPMIH (1-385 aa encoded by B C036035)
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. DHX36 (DEAH box protein 36), also known as MLE-like protein 1 and RNA helicase associated with AU-rich element ARE (RHAU), belongs to RNA helicase of the DEAH family and may function in sex development and spermatogenesis. It is expressed in testis and is evolutionary conserved with true orthologs in almost all animal species. DHX36 plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. DHX36 is required for early embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Asp-Glu-Ala-His; ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DEAH-box protein 36; G4 resolvase-1; G4-resolvase-1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein; unnamed protein product
Gene Aliases: 2810407E23Rik; DDX36; G4R1; mKIAA1488; MLEL1; RHAU
UniProt ID: (Human) Q9H2U1, (Mouse) Q8VHK9, (Rat) D4A2Z8
Entrez Gene ID: (Human) 170506, (Mouse) 72162, (Rat) 310461
magnesium ion binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
G-quadruplex RNA binding
nucleic acid binding
DNA helicase activity
single-stranded DNA binding
RNA binding
RNA helicase activity
double-stranded RNA binding
mRNA 3'-UTR binding
protein binding
ATP binding
DNA-dependent ATPase activity
ATPase activity
mRNA 3'-UTR AU-rich region binding
histone deacetylase binding
mRNA 5'-UTR binding
G-quadruplex DNA binding
telomerase RNA binding
pre-miRNA binding
G-quadruplex unwinding activity
catalytic activity, acting on a nucleic acid
ossification
positive regulation of myeloid dendritic cell cytokine production
regulation of transcription from RNA polymerase III promoter
spermatogenesis
response to virus
positive regulation of gene expression
negative regulation of translation
positive regulation of mRNA 3'-end processing
positive regulation of telomere maintenance
positive regulation of interferon-alpha production
cellular response to heat
cellular response to UV
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
regulation of mRNA stability
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
positive regulation of cardioblast differentiation
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of dendritic spine morphogenesis
3'-UTR-mediated mRNA destabilization
telomerase RNA stabilization
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of hematopoietic progenitor cell differentiation
cellular response to arsenite ion
positive regulation of telomere maintenance via telomere lengthening
positive regulation of intracellular mRNA localization
positive regulation of cytoplasmic translation
positive regulation of translation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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