PA1-32440 detects DJ1 from mouse, human, rat, hamster and fish samples.
PA1-32440 has been successfully used in immunocytochemistry, immunoprecipitation, Western blot applications.
The PA1-32440 immunogen is: Synthetic peptide corresponding to residues between 150-189 of human DJ-1 (the C-terminus).
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
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Protein Aliases: Contraception-associated protein 1; CTA-215D11.1; DJ-1; DJ1; epididymis secretory sperm binding protein Li 67p; Fertility protein SP22; FLJ27376; FLJ34360; FLJ92274; Maillard deglycase; Oncogene DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; Parkinson disease protein 7 homolog; parkinson protein 7; Parkinsonism-associated deglycase; Protein CAP1; protein deglycase DJ-1; Protein DJ-1; protein DJ-1-like protein; Protein/nucleic acid deglycase DJ-1; RNA-binding protein regulatory subunit
Gene Aliases: CAP1; DJ-1; DJ1; HEL-S-67p; PARK7; SP22