Search
Proteintech
DKC1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
25420-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DKC1 Fusion Protein Ag7992 (157-514 aa encoded by BC009928)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VRLHNAIEG GTQLSRALET LTGALFQRPP LIAAVKRQLR VRTIYESKMI EYDPERRLGI FWVSCEAGTY IRTLCVHLGL LLGVGGQMQE LRRVRSGVMS EKDHMVTMHD VLDAQWLYDN HKDESYLRRF VYPLEKLLTS HKRLVMKDSA VNAICYGAKI MLPGVLRYED GIEVNQEIVV ITTKGEAICM AIALMTTAVI STCDHGIVAK IKRVIMERDT YPRKWGLGPK ASQKKLMIKQ GLLDKHGKPT DSTPATWKQE YVDYSESAKK EVVAEVVKAP QVVAEAAKTA KRKRESESES DETPPAAPQL IKKEKKKSKK DKKAKAGLES GAEPGDGDSD TTKKKKKKKK AKEVELVSE (157-514 aa encoded by BC009928)
Target Information
This gene is a member of the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CBF5 homolog; dyskeratosis congenita 1, dyskerin; Dyskerin; H/ACA ribonucleoprotein complex subunit 4; H/ACA ribonucleoprotein complex subunit 4 isoform 3; H/ACA ribonucleoprotein complex subunit DKC1; Nopp140-associated protein of 57 kDa; nucleolar protein; Nucleolar protein family A member 4; Nucleolar protein NAP57; snoRNP protein DKC1
Gene Aliases: CBF5; CHINE1; DKC; DKC1; DKCX; NAP57; NOLA4; XAP101
UniProt ID: (Human) O60832
Entrez Gene ID: (Human) 1736
enzyme-directed rRNA pseudouridine synthesis
box H/ACA snoRNA 3'-end processing
pseudouridine synthesis
rRNA processing
RNA processing
telomere maintenance via telomerase
RNA modification
rRNA pseudouridine synthesis
snRNA pseudouridine synthesis
positive regulation of telomere maintenance via telomerase
box H/ACA snoRNA metabolic process
ribosome biogenesis
scaRNA localization to Cajal body
telomerase RNA stabilization
protein localization to Cajal body
regulation of telomerase RNA localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
telomerase holoenzyme complex assembly
mRNA pseudouridine synthesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support