In sandwich ELISAs, less than 6% cross-reactivity with recombinant human Dkk-1 and less than 0.1% cross-reactivity with recombinant mouse (rm) Dkk-2, rmDkk-3, and rmDkk-4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
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Protein Aliases: dickkopf related protein-1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; DKK-1; hDkk-1
Gene Aliases: Dkk1; mdkk-1
UniProt ID: (Mouse) O54908
Entrez Gene ID: (Mouse) 13380