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Invitrogen
DLC1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
PA5-28443
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 43 of Human DLC1
Conjugate
Unconjugated
Form
Liquid
Concentration
0.84 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545919
Product Specific Information
Recommended positive controls: H1299, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (100%), Dog (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ARHGAP 7; Deleted in liver cancer 1 protein; deleted in liver cancer 1 variant 2; deleted in liver cancer variant 4; DLC 1; DLC-1; FLJ21120; HP protein; p122 RhoGAP; Rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; Rho-type GTPase-activating protein 7; StAR-related lipid; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; STARD 12; StARD12; START domain-containing protein 12; transfer protein 12
Gene Aliases: ARHGAP7; DLC1; HP; KIAA1723; p122-RhoGAP; STARD12
UniProt ID: (Human) Q96QB1
Entrez Gene ID: (Human) 10395
neural tube closure
heart morphogenesis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
negative regulation of cell proliferation
regulation of cell shape
hindbrain morphogenesis
actin cytoskeleton organization
negative regulation of cell migration
forebrain development
regulation of actin cytoskeleton organization
negative regulation of Rho protein signal transduction
positive regulation of protein dephosphorylation
positive regulation of GTPase activity
focal adhesion assembly
regulation of small GTPase mediated signal transduction
negative regulation of stress fiber assembly
negative regulation of focal adhesion assembly
positive regulation of execution phase of apoptosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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