PA5-28443 targets DLC1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28443 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 43 of Human DLC1.
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This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers. Alternative splicing at this locus results in several transcript variants encoding different isoforms.
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Protein Aliases: ARHGAP7; Deleted in liver cancer 1 protein; deleted in liver cancer 1 variant 2; deleted in liver cancer variant 4; DLC-1; HP; HP protein; p122-RhoGAP; Rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; rho-type GTPase-activating pr; Rho-type GTPase-activating protein 7; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; STARD12; START domain-containing protein 12
Gene Aliases: ARHGAP7; DLC1; HP; KIAA1723; p122-RhoGAP; STARD12
UniProt ID: (Human) Q96QB1
Entrez Gene ID: (Human) 10395