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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 1 publication 1 publication |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
DLL4 Fusion Protein Ag16140 (317-530 aa encoded by BC106950) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.22 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: TGVDCELEL SECDSNPCRN GGSCKDQEDG YHCLCPPGYY GLHCEHSTLS CADSPCFNGG SCRERNQGAN YACECPPNFT GSNCEKKVDR CTSNPCANGG QCLNRGPSRM CRCRPGFTGT YCELHVSDCA RNPCAHGGTC HDLENGLMCT CPAGFSGRRC EVRTSIDACA SSPCFNRATC YTDLSTDTFV CNCPYGFVGS RCEFPVGLPP SFPWV (317-530 aa encoded by BC106950)
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 protein; Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344; notch ligand delta-2; notch ligand DLL4
Gene Aliases: AOS6; Delta4; DLL4; hdelta2; UNQ1895/PRO4341
UniProt ID: (Human) Q9NR61, (Mouse) Q9JI71
Entrez Gene ID: (Human) 54567, (Mouse) 54485
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