Recommended positive controls: Jurkat, mouse brain, rat brain.
Predicted reactivity: Cow: 87%; Dog: 92%; Guinea Pig: 100%; Horse: 86%; Mouse: 92%.
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
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Protein Aliases: DII A; distal-less homeo box 2; DLX-5; homeobox Dlx5; Homeobox protein DLX-2; Homeobox protein TES-1
Gene Aliases: AW121999; Dlx-2; DLX2; Dlx5; TES-1; TES1
Molecular Function: homeodomain transcription factor