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Invitrogen
DLX2 Polyclonal Antibody
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FIGURE: 1 / 1
DLX2 Antibody (PA5-85547) in WB
Western blot analysis of DLX2 in various lysates. Samples were incubated with DLX2 polyclonal antibody (Product # PA5-85547) using a dilution of 1:20,000. A. 30 μg 293T whole cell lysate/extract; B. 30 μg whole cell lysate/extract of human DLX2-transfected 293T cells. Separated by 12 % SDS-PAGE.
Product Details
PA5-85547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DLX2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (93%), Bovine (95%).
Positive Control: human DLX2-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DII A; distal-less homeo box 2; Homeobox protein DLX-2; Homeobox protein TES-1; unnamed protein product
Gene Aliases: AW121999; Dlx-2; DLX2; TES-1; TES1
UniProt ID: (Human) Q07687, (Mouse) P40764
Entrez Gene ID: (Human) 1746, (Mouse) 13392
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
single-stranded RNA binding
protein binding
sequence-specific double-stranded DNA binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
brain development
proximal/distal pattern formation
neuroblast differentiation
subpallium development
hippocampus development
olfactory bulb development
forebrain neuron differentiation
cerebral cortex GABAergic interneuron differentiation
cerebral cortex GABAergic interneuron fate commitment
cell differentiation
odontogenesis of dentin-containing tooth
positive regulation of cell differentiation
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of photoreceptor cell differentiation
embryonic cranial skeleton morphogenesis
embryonic skeletal system development
oligodendrocyte differentiation
negative regulation of oligodendrocyte differentiation
branching morphogenesis of a nerve
cartilage development
GABAergic neuron differentiation
positive regulation of amacrine cell differentiation
transcription from RNA polymerase II promoter
multicellular organism development
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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