EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
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Protein Aliases: (rat homolog) mouse id-associated protein 1; DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; DnaJ homolog subfamily C member 2, N-terminally processed; Gliosarcoma-related antigen MIDA1; Id associate 1; M-phase phosphoprotein 11; MIDA1; Mouse Id associate 1; zuotin related factor 1; zuotin related factor 2; Zuotin-related factor 1
Gene Aliases: AU020218; DNAJC2; MIDA1; MPHOSPH11; MPP11; ZRF1; Zrf2; ZUO1
Molecular Function: chaperone