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Proteintech
DNMBP Polyclonal Antibody
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Product Details
17191-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNMBP Fusion Protein Ag10973 (473-824 aa encoded by BC041628)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RVLQQLQVF TFFPESLPAT KKPFERKTID RQSARKPLLG LPSYMLQSEE LRASLLARYP PEKLFQAERN FNAAQDLDVS LLEGDLVGVI KKKDPMGSQN RWLIDNGVTK GFVYSSFLKP YNPRRSHSDA SVGSHSSTES EHGSSSPRFP RQNSGSTLTF NPSSMAVSFT SGSCQKQPQD ASPPPKEWDQ GTLSASLNPS NSESSPSRCP SDPDSTSQPR SGDSADVARD VKQPTATPRS YRNFRHPEIV GYSVPGRNGQ SQDLVKGCAR TAQAPEDRST EPDGSEAEGN QVYFAVYTFK ARNPNELSVS ANQKLKILEF KDVTGNTEWW LAEVNGKKGY VPSNYIRKTE YT (473-824 aa encoded by BC041628)
Target Information
The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dynamin binding protein; Dynamin-binding protein; Scaffold protein Tuba
Gene Aliases: 2410003L07Rik; 2410003M15Rik; ARHGEF36; DNMBP; KIAA1010; TUBA
UniProt ID: (Human) Q6XZF7, (Mouse) Q6TXD4
Entrez Gene ID: (Human) 23268, (Mouse) 71972, (Rat) 309362
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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