FIGURE: 1 / 9
Immunogen sequence: KDLIAWQIP FLAEGIRIHG DKVTEALRPF HERMEACFKQ LKEKVEKEYG VRIMPSSLDD RRGSRPRSMV RSFTMPSSSR PLSVASVSSL SSDSTPSRPG SDGFALEPLL PKKMHSRSQD KLDKDDLEKE KKDKKKEKRN SKHQEIFEKE FKPTDISLQQ SEAVILSETI SPLRPQRPKS QVMNVIGSER RFSVSPSSPS SQQTPPPVTP RAKLSFSMQS SLELNGMTGA DVADVPPPLP LKGSVADYGN LMENQDLLGS PTPPPPPPHQ RHLPPPLPSK TPPPPPPKTT RKQTSVDSGI VQ (1565-1865 aa encoded by B C146857)
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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Protein Aliases: 180 kDa protein downstream of CRK; Dedicator of cytokinesis protein 1; dock 180; DOCK180; DOwnstream of CrK; RP11-82L9.1
Gene Aliases: ced5; DOCK1; DOCK180
UniProt ID: (Human) Q14185
Entrez Gene ID: (Human) 1793
Molecular Function: guanyl-nucleotide exchange factor