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Proteintech
DOCK8 Polyclonal Antibody
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Product Details
11622-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DOCK8 Fusion Protein Ag2040 (257-606 aa encoded by BC019102)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EVYKLVIPI LEAHREFRKL TLTHSKLQRA FDSIVNKDHK RMFGTYFRVG FFGSKFGDLD EQEFVYKEPA ITKLPEISHR LEAFYGQCFG AEFVEVIKDS TPVDKTKLDP NKAYIQITFV EPYFDEYEMK DRVTYFEKNF NLRRFMYTTP FTLEGRPRGE LHEQYRRNTV LTTMHAFPYI KTRISVIQKE EFVLTPIEVA IEDMKKKTLQ LAVAINQEPP DAKMLQMVLQ GSVGATVNQG PLEVAQVFLA EIPADPKLYR HHNKLRLCFK EFIMRCGEAV EKNKRLITAD QREYQQELKK NYNKLKENLR PMIERKIPEL YKPIFRVESQ KRDSFHRSSF RKCETQLSQG S (257-606 aa encoded by BC019102)
Target Information
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1200017A24Rik; Dedicator of cytokinesis protein 8; epididymis luminal protein 205; unnamed protein product
Gene Aliases: 1200017A24Rik; 5830472H07Rik; A130095G14Rik; AI461977; DOCK8; HEL-205; HIES2; MRD2; ZIR8
UniProt ID: (Human) Q8NF50, (Mouse) Q8C147
Entrez Gene ID: (Human) 81704, (Mouse) 76088
immunological synapse formation
small GTPase mediated signal transduction
regulation of Rho protein signal transduction
dendritic cell migration
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
memory T cell proliferation
negative regulation of T cell apoptotic process
positive regulation of establishment of T cell polarity
cellular response to chemokine
positive regulation of T cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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