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Immunogen sequence: VLRATKLGIP YRVIHNASIM NAVGCCGLQL YKFGETVSIV FWTDTWRPES FFDKVKKNRQ NGMHTLCLLD IKVKEQSLEN LIKGRKIYEP PRYMS
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Protein Aliases: Diphthamide biosynthesis methyltransferase; Diphthine methyl ester synthase; diphthine synthase; DPH5 homolog; protein x 0011
Gene Aliases: AD-018; CGI-30; DPH5; HSPC143; NPD015
UniProt ID: (Human) Q9H2P9
Entrez Gene ID: (Human) 51611
Molecular Function: methyltransferase