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Proteintech
DR4 Polyclonal Antibody
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Product Details
24063-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DR4 Fusion Protein Ag20927 (261-468 aa encoded by BC012866)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CCCIGSGCG GDPKCMDRVC FWRLGLLRGP GAEDNAHNEI LSNADSLSTF VSEQQMESQE PADLTGVTVQ SPGEAQCLLG PAEAEGSQRR RLLVPANGAD PTETLMLFFD KFANIVPFDS WDQLMRQLDL TKNEIDVVRA GTAGPGDALY AMLMKWVNKT GRNASIHTLL DALERMEERH AKEKIQDLLV DSGKFIYLED GTGSAVSLE (261-468 aa encoded by BC012866)
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD261; cytotoxic TRAIL receptor; Death receptor 4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF-related apoptosis-inducing ligand receptor 1; TRAIL R1; TRAIL receptor 1; TRAIL-R1; Tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily, member 10a; unnamed protein product
Gene Aliases: APO2; CD261; DR4; TNFRSF10A; TRAILR-1; TRAILR1
UniProt ID: (Human) O00220
Entrez Gene ID: (Human) 8797
apoptotic process
signal transduction
activation of NF-kappaB-inducing kinase activity
extrinsic apoptotic signaling pathway via death domain receptors
TRAIL-activated apoptotic signaling pathway
positive regulation of apoptotic process
cellular response to mechanical stimulus
extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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