A suggested positive control is Hela cell lysate.
PA5-19876 can be used with blocking peptide PEP-0011.
DR4 antibody has no cross reaction to DR5
The PA5-19876 immunogen is located within the last 50 amino acids of DR4.
Predicted molecular ~ 50kD. In Western blot applications, this antibody has been observed to detect a band at: 55kD (Post-modification: 1 N-linked glycosylation)
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappa-B activation in many tissues and cells.
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Protein Aliases: APO2; CD261; cytotoxic TRAIL receptor; Death receptor 4; DR4; MGC9365; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; TRAILR-1; TRAILR1; Tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
Gene Aliases: APO2; CD261; DR4; TNFRSF10A; TRAILR-1; TRAILR1
UniProt ID: (Human) O00220
Entrez Gene ID: (Human) 8797