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DUSP1/MKP1 Polyclonal Antibody

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DUSP1/MKP1 Polyclonal Antibody

Product Details

BS-1851R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human DUSP1, amino acids 151-250.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3CH134/CL100 PTPase; CL 100; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; EC 3.1.3.16; EC 3.1.3.48; MAP kinase phosphatase 1; MAP kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; Mitogen-activated protein kinase phosphatase 1; mitogen-activated protein kinase phosphatase-1; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; Protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase CL100; Protein-tyrosine phosphatase ERP; Protein-tyrosine phosphatase non-receptor type 16; serine/threonine specific protein phosphatase; unnamed protein product

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Gene Aliases: 3CH134; CL100; DUSP1; erp; HVH1; MKP-1; MKP1; PTPN10; Ptpn16; U19515; VH1

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UniProt ID: (Human) P28562, (Rat) Q64623, (Mouse) P28563

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Entrez Gene ID: (Human) 1843, (Rat) 114856, (Mouse) 19252

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Function(s)
phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding protein tyrosine/serine/threonine phosphatase activity hydrolase activity MAP kinase tyrosine/serine/threonine phosphatase activity growth factor binding mitogen-activated protein kinase binding protein tyrosine/threonine phosphatase activity phosphatase activity protein phosphatase
Process(es)
endoderm formation negative regulation of cell adhesion signal transduction negative regulation of cell proliferation response to light stimulus response to estradiol response to retinoic acid cellular response to hormone stimulus response to testosterone peptidyl-tyrosine dephosphorylation intracellular signal transduction peptidyl-threonine dephosphorylation response to hydrogen peroxide positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAP kinase activity negative regulation of MAPK cascade response to glucocorticoid negative regulation of meiotic cell cycle response to cAMP response to calcium ion peptidyl-serine dephosphorylation ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade negative regulation of monocyte chemotaxis regulation of mitotic cell cycle spindle assembly checkpoint negative regulation of p38MAPK cascade cellular response to chemokine negative regulation of DNA biosynthetic process inactivation of MAPK activity protein dephosphorylation response to organic substance mitotic cell cycle arrest cell cycle dephosphorylation regulation of apoptotic process
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