This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 79%; Human: 100%; Mouse: 79%; Pig: 86%; Rabbit: 86%; Rat: 79%
DUSP11 (dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)) is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus, and is novel in that it binds directly to RNA and splicing factors, and thus suggested to participate in nuclear mRNA metabolism.
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Protein Aliases: dual specificity phosphatase 11; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1; PIR1; RNA/RNP complex 1-interacting; RNA/RNP complex-1-interacting phosphatase; RNA/RNP complex-interacting phosphatase; serine/threonine specific protein phosphatase
Gene Aliases: 2010300F21Rik; AI481497; BOS_11394; DUSP11; PIR1