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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 461 and 665 of Human DUSP16|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||Assay-Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29888 targets DUSP16 in IF, IHC (P), ChIP and WB applications and shows reactivity with Human samples.
The PA5-29888 immunogen is recombinant fragment corresponding to a region within amino acids 461 and 665 of Human DUSP16.
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAPK phosphatase-7; Mitogen-activated protein kinase phosphatase 7; MKP-7; MKP7
DUSP16; KIAA1700; MKP-7; MKP7