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Invitrogen
DUSP4 Polyclonal Antibody
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FIGURE: 1 / 6
DUSP4 Antibody (PA5-99652) in ICC/IF
Immunofluorescent analysis of DUSP4 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with DUSP4 polyclonal antibody (Product # PA5-99652) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
Product Details
PA5-99652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DUSP4(Accession Q13115), corresponding to amino acid residues P88-T138.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MKP-2.
Target Information
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP-4; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP II; MKPII; serine/threonine specific protein phosphatase; unnamed protein product; VH1 homologous phosphatase 2
Gene Aliases: 2700078F24Rik; AI844617; BB104621; DUSP4; E130306H24Rik; HVH2; MKP-2; MKP2; TYP; VH2
UniProt ID: (Human) Q13115, (Rat) Q62767, (Mouse) Q8BFV3
Entrez Gene ID: (Human) 1846, (Rat) 60587, (Mouse) 319520
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/threonine phosphatase activity
hydrolase activity
phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
MAP kinase phosphatase activity
MAP kinase threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein phosphatase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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