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This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
The DYNLRB1 gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18.
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Protein Aliases: Bithoraxoid-like protein; BLP; Dynein light chain 2A, cytoplasmic; Dynein light chain roadblock-type 1; dynein, cytoplasmic, light polypeptide 2A; dynein, light chain, roadblock-type 1; Dynein-associated protein Km23; Roadblock domain-containing protein 1; ROBL/LC7-like 1
Gene Aliases: BITH; BLP; DNCL2A; DNLC2A; DYNLRB1; HSPC162; ROBLD1
UniProt ID: (Human) Q9NP97
Entrez Gene ID: (Human) 83658
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