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Immunogen sequence: AFVVDEVSNIV KEAIESAIGG NAYQHSKVNQ WTTNVVEQTL SQLTKLGKPF KYIVTCVIMQ KNGAGLHTAS S
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 100%.
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dynein light chain Tctex-type 1; dynein, light chain, Tctex-type 1; Protein CW-1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1
Gene Aliases: CW-1; DYNLT1; TCTEL1; TCTEX-1; TCTEX1
UniProt ID: (Human) P63172
Entrez Gene ID: (Human) 6993
Molecular Function: microtubule or microtubule-binding cytoskeletal protein