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Proteintech
DYRK2 Polyclonal Antibody
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Product Details
21979-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DYRK2 fusion protein Ag13480
Conjugate
Form
Liquid
Concentration
300 µg/mL
Amount
45 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGLGAGATRS GVGTGPPSPI ALPPLRASNA AAAAHTIGGS KHTMNDHLHV GSHAHGQIQV QQLFEDNSNK RTVLTTQPNG LTTVGKTGLP VVPERQLDSI HRRQGSSTSL KSMEGMGKVK ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE IYFLGLNAKK RQGMTGGPNN GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY DHKVHQHVAL KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT
Target Information
DYRK2 (also known as dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2) belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development and is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 expressed in E. coli demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. DYRK2 also regulates p53 to induce apoptosis in response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; Dyrk2; unnamed protein product
Gene Aliases: 1810038L18Rik; DYRK2
UniProt ID: (Human) Q92630, (Mouse) Q5U4C9
Entrez Gene ID: (Human) 8445, (Mouse) 69181, (Rat) 314862
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
manganese ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
ubiquitin binding
protein phosphorylation
apoptotic process
smoothened signaling pathway
phosphorylation
peptidyl-tyrosine phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of glycogen biosynthetic process
negative regulation of NFAT protein import into nucleus
cellular response to DNA damage stimulus
negative regulation of calcineurin-NFAT signaling cascade
regulation of signal transduction by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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