This antibody is predicted to react with bovine and porcine based on sequence homology.
Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.
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Protein Aliases: Bone proteoglycan II; Decorin; dermatan sulphate proteoglycans II; PG-S2; PG40; proteoglycan core protein; small leucine-rich protein 1B
Gene Aliases: CSCD; DC; DCN; DSPG2; mDcn; PG40; PGII; PGS2; SLRR1B