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Defensin alpha-3 Antibody (PA5-67958) in IHC (P)
Immunohistochemical analysis of Defensin alpha 3 staining in human skeletal muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with Defensin alpha-3 Polyclonal Antibody (Product # PA5-67958) at room temperature and detected using an HRP conjugated compact polymer system.... View More
Product Details
PA5-67958
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human Defensin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.3, with 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2691513
Target Information
Defensin alpha-1 is part of a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. Defensins are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The Defensin alpha-1 protein is encoded by the DFA1 gene and is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8, and this gene differs from defensin, alpha 3 by only one amino acid. The DFA1 gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms of Defensin alpha-1 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: defensin 3, neutrophil-specific; Defensin, alpha 3; defensin, alpha 3, neutrophil-specific; HNP-3; HP-3; Neutrophil defensin 3; neutrophil peptide 3
Gene Aliases: DEF3; DEFA3; HNP-3; HNP3; HP-3; HP3
UniProt ID: (Human) P59666
Entrez Gene ID: (Human) 1668
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