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Invitrogen
Dynactin 1 Polyclonal Antibody
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Product Details
PA5-149232
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human Dynactin Subunit 1/DCTN1, Ala1145-Ser1278
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DP 150; DP-150; DP150; dynactin 1 (p150, glued homolog, Drosophila); Dynactin subunit 1; Dynactin1; HMN7B; OTTHUMP00000202491; p135; p150 glued; p150 glued homolog; p150-glued; p150glued; unnamed protein product
Gene Aliases: DAP-150; DCTN1; DP-150; HMND14; P135
UniProt ID: (Human) Q14203
Entrez Gene ID: (Human) 1639
establishment of mitotic spindle orientation
mitotic cell cycle
nuclear migration
nervous system development
neuromuscular junction development
centriole-centriole cohesion
ventral spinal cord development
positive regulation of microtubule polymerization
melanosome transport
microtubule anchoring at centrosome
retrograde transport, endosome to Golgi
neuromuscular process
nuclear envelope disassembly
cell division
regulation of mitotic spindle organization
motor behavior
neuron cellular homeostasis
positive regulation of microtubule nucleation
axonal transport
maintenance of synapse structure
positive regulation of neuromuscular junction development
non-motile cilium assembly
neuron projection maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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