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Product Details
11361-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Dynamitin (1-401 AA) Fusion Protein Ag1902 (1-401 aa encoded by BC014083)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This antibody is against the full length p50 dynamitin.
Immunogen sequence: MADPKYADL PGIARNEPDV YETSDLPEDD QAEFDAEELT STSVEHIIVN PNAAYDKFKD KRVGTKGLDF SDRIGKTKRT GYESGEYEML GEGLGVKETP QQKYQRLLHE VQELTTEVEK IKTTVKESAT EEKLTPVLLA KQLAALKQQL VASHLEKLLG PDAAINLTDP DGALAKRLLL QLEATKNSKG GSGGKTTGTP PDSSLVTYEL HSRPEQDKFS QAAKVAELEK RLTELETAVR CDQDAQNPLS AGLQGACLME TVELLQAKVS ALDLAVLDQV EARLQSVLGK VNEIAKHKAS VEDADTQSKV HQLYETIQRW SPIASTLPEL VQRLVTIKQL HEQAMQFGQL LTHLDTTQQM IANSLKDNTT LLTQVQTTMR ENLATVEGNF ASIDERMKKL GK (1-401 aa encoded by BC014083)
Target Information
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 50 kDa dynein-associated polypeptide; DCTN-50; dynactin 2 (p50); Dynactin complex 50 kDa subunit; Dynactin subunit 2; epididymis secretory protein Li 77; GMP23-48K; Growth cone membrane protein 23-48K; p50 dynamitin
Gene Aliases: 2310042E05Rik; C130077D06Rik; C87049; DCTN-50; DCTN2; DCTN50; DYNAMITIN; GMP23-48K; HEL-S-77; p50; RBP50
UniProt ID: (Human) Q13561, (Rat) Q6AYH5, (Mouse) Q99KJ8
Entrez Gene ID: (Human) 10540, (Rat) 299850, (Mouse) 69654
Molecular Function:
microtubule binding motor protein
G2/M transition of mitotic cell cycle
ER to Golgi vesicle-mediated transport
microtubule-based process
mitotic spindle organization
mitotic nuclear division
cell proliferation
antigen processing and presentation of exogenous peptide antigen via MHC class II
melanosome transport
protein localization to centrosome
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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