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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (330 SISSAVKSAPEENSRE 345) of EBI2/GPR183 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
G-protein coupled receptor 183 (EBI2) belongs to the G-protein coupled receptor 1 family of proteins. It is an orphan seven-transmembrane receptor originally identified as most up-regulated gene (>200-fold) in EBV-infected cells. It plays a central role during humoral immunity. It promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. It is expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. It is also reported to be highly expressed in lung, heart and gastrointestinal tract. EBI2 deficiency in mice led to a reduction in the early antibody response to a T-dependent antigen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EBI2; EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); epstein-Barr virus-induced G-protein coupled receptor 2; RP11-461N23.2