Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.
Protein Aliases: ECE-2; EEF1AKMT4-ECE2 readthrough transcript protein; endothelin converting enzyme 2; Endothelin-converting enzyme 2; Endothelin-converting enzyme 2 region; Methyltransferase-like region
Gene Aliases: 1810009K13Rik; 6330509A19Rik; 9630025D12Rik; BB127715; ECE2; EEF1AKMT4-ECE2; KIAA0604; UNQ403/PRO740