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Proteintech

ECE2 Polyclonal Antibody

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View all (8) ECE2 antibodies

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ECE2 Polyclonal Antibody

Product Details

15418-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400
-

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ECE2 Fusion Protein Ag7706 (1-255 aa encoded by BC005835)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Amount

40.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASPGAGRA PPELPERNCG YREVEYWDQR YQGAADSAPY DWFGDFSSFR ALLEPELRPE DRILVLGCGN SALSYELFLG GFPNVTSVDY SSVVVAAMQA RYAHVPQLRW ETMDVRKLDF PSASFDVVLE KGTLDALLAG ERDPWTVSSE GVHTVDQVLS EVSRVLVPGG RFISMTSAAP HFRTRHYAQA YYGWSLRHAT YGSGFHFHLY LMHKGGKLSV AQLALGAQIL SPPRPPTSPC FLQDSDHEDF LSAIQL (1-255 aa encoded by B C005835)

Target Information

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ECE-2; ECE-2B; ECE-2B; alternatively spliced; EEF1A lysine methyltransferase 4; EEF1AKMT4-ECE2; EEF1AKMT4-ECE2 readthrough transcript protein; endothelin converting enzyme 2; Endothelin-converting enzyme 2; metalloprotease; unnamed protein product

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Gene Aliases: 1810009K13Rik; 6330509A19Rik; 9630025D12Rik; BB127715; ECE2; EEF1AKMT4; KIAA0604; UNQ403/PRO740

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UniProt ID: (Human) P0DPD6, (Mouse) B2RQR8

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Entrez Gene ID: (Human) 9718, (Mouse) 107522, (Rat) 408243

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Function(s)
catalytic activity metalloendopeptidase activity protein binding methyltransferase activity peptidase activity metallopeptidase activity transferase activity hydrolase activity metal ion binding rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity metalloprotease methyltransferase
Process(es)
proteolysis G-protein coupled receptor signaling pathway cell-cell signaling protein processing peptide hormone processing methylation metabolic process
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