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Bioss
ECM1 Polyclonal Antibody
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FIGURE: 1 / 3
ECM1 Antibody (BS-0776R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse esophagus; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with ECM1 Polyclonal Antibody, Unconjugated (bs-0776R) at 1:400 overnight at 4°C, followed by a FITC conjugated secondary antibody for 90... View More
Product Details
BS-0776R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from mouse ECM1, amino acids 488-567.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ECM1, also referred to as extracellular matrix protein 1, is a protein that plays a significant role in regulating extracellular matrix organization and cell adhesion. It is expressed in various tissues, including the skin, lung, and liver, and is involved in the development and progression of several diseases, including cancer and dermatological disorders. The protein interacts with several extracellular matrix proteins, such as collagen and fibronectin, and is involved in the regulation of cell proliferation, migration, and invasion. ECM1 is also involved in endochondral bone formation, angiogenesis, and tumor biology. It interacts with various extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae, and certain viscera. Different isoforms of ECM1 have been described in alternatively spliced transcript variants. Diseases associated with ECM1 include Lipoid Proteinosis Of Urbach And Wiethe and Lichen Sclerosus Et Atrophicus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Extracellular matrix protein 1; RP11-54A4.6; Secretory component p85; testicular tissue protein Li 61
Gene Aliases: AI663821; ECM1; p85; URBWD
UniProt ID: (Human) Q16610, (Mouse) Q61508, (Rat) Q62894
Entrez Gene ID: (Human) 1893, (Mouse) 13601, (Rat) 116662
ossification
angiogenesis
positive regulation of endothelial cell proliferation
negative regulation of cytokine-mediated signaling pathway
platelet degranulation
regulation of type 2 immune response
regulation of transcription from RNA polymerase II promoter
inflammatory response
signal transduction
negative regulation of peptidase activity
negative regulation of bone mineralization
biomineral tissue development
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
regulation of T cell migration
regulation of bone mineralization
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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