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Invitrogen
EDG2 Polyclonal Antibody
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FIGURE: 1 / 2
EDG2 Antibody (PA5-106830) in IHC (P)
Immunohistochemistry analysis of EDG2 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with EDG2 polyclonal antibody (Product # PA5-106830) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LPAR1(Accession Q92633), corresponding to amino acid residues I11-I61.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total EDG2.
Target Information
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDG2; endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; G-protein coupled receptor 26; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; Rec1.3; unnamed protein product; ventricular zone gene 1; VZG-1
Gene Aliases: AI326300; edg-2; EDG2; Gpcr26; Gpcr91; Kdt2; LPA1; LPAR1; Mrec1.3; rec.1.3; vzg-1; VZG1
UniProt ID: (Human) Q92633, (Rat) P61794, (Mouse) P61793
Entrez Gene ID: (Human) 1902, (Rat) 116744, (Mouse) 14745
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
negative regulation of neuron projection development
oligodendrocyte development
cerebellum development
optic nerve development
neurogenesis
corpus callosum development
bleb assembly
positive regulation of Rho protein signal transduction
myelination
Golgi to plasma membrane protein transport
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cilium assembly
positive regulation of stress fiber assembly
cell chemotaxis
regulation of vesicle-mediated transport
positive regulation of dendritic spine development
protein localization to cilium
cellular response to oxygen levels
positive regulation of smooth muscle cell chemotaxis
regulation of synaptic vesicle cycle
regulation of postsynaptic neurotransmitter receptor internalization
negative regulation of cAMP/PKA signal transduction
negative regulation of cilium assembly
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
activation of MAPK activity
positive regulation of cell death
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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