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Product Details
20499-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EIF2AK1 Fusion Protein Ag14236 (281-630 aa encoded by BC006524)
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FAEPTPEKE KRFGESDTEN QNNKSVKYTT NLVIRESGEL ESTLELQENG LAGLSASSIV EQQLPLRRNS HLEESFTSTE ESSEENVNFL GQTEAQYHLM LHIQMQLCEL SLWDWIVERN KRGREYVDES ACPYVMANVA TKIFQELVEG VFYIHNMGIV HRDLKPRNIF LHGPDQQVKI GDFGLACTDI LQKNTDWTNR NGKRTPTHTS RVGTCLYASP EQLEGSEYDA KSDMYSLGVV LLELFQPFGT EMERAEVLTG LRTGQLPESL RKRCPVQAKY IQHLTRRNSS QRPSAIQLLQ SELFQNSGNV NLTLQMKIIE QEKEIAELKK QLNLLSQDKG VRDDGKDGGV G (281-630 aa encoded by BC006524)
Target Information
EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; Heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; Hemin-sensitive initiation factor 2-alpha kinase; hHRI
Gene Aliases: EIF2AK1; HCR; HRI; KIAA1369; PRO1362
UniProt ID: (Human) Q9BQI3
Entrez Gene ID: (Human) 27102
acute inflammatory response
phagocytosis
response to stress
negative regulation of cell proliferation
response to external stimulus
regulation of translational initiation by eIF2 alpha phosphorylation
regulation of eIF2 alpha phosphorylation by heme
macrophage differentiation
negative regulation of translational initiation by iron
protoporphyrinogen IX metabolic process
protein autophosphorylation
negative regulation of hemoglobin biosynthetic process
iron ion homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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