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Proteintech
ELL Polyclonal Antibody
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Product Details
51044-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ELL Fusion Protein Ag0617 (1-500 aa encoded by BC049195)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAALKEDRS YGLSCGRVSD GSKVSVFHVK LTDSALRAFE SYRARQDSVS LRPSIRFQGS QGHISIPQPD CPAEARTFSF YLSNIGRDNP QGSFDCIQQY VSSHGEVHLD CLGSIQDKIT VCATDDSYQK ARQSMAQAEE ETRSRSAIVI KAGGRYLGKK VQFRKPAPGA TDAVPSRKRA TPINLASAIR KSGASAVSGG SGVSQRPFRD RVLHLLALRP YRKAELLLRL QKDGLTQADK DALDGLLQQV ANMSAKDGTC TLQDCMYKDV QKDWPGYSEG DQQLLKRVLV RKLCQPQSTG SLLGDPAASS PPGERGRSAS PPQKRLQPPD FIDPLANKKP RISHFTQRAQ PAVNGKLGVP NGREALLPTP GPPASTDTLS SSTHLPPRLE PPRAHDPLAD VSNDLGHSGR DCEHGEAAAP APTVRLGLPL LTDCAQPSRP HGSPSRSKPK KKSKKHKDKE RAAEDKPRAQ LPDCAPATHA TPGAPADTPG LNGTCSVSSV PT (1-500 aa encoded by BC049195)
Target Information
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Eleven-nineteen lysine-rich leukemia protein; ELL; ELL gene (11-19 lysine-rich leukemia gene); ELL/KMT2A fusion protein; elongation factor RNA polymerase II; KMT2A/ELL fusion protein; protein phosphatase 1, regulatory subunit 68; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN); unnamed protein product
Gene Aliases: C19orf17; ELL; ELL1; MEN; PPP1R68
UniProt ID: (Human) P55199, (Mouse) O08856
Entrez Gene ID: (Human) 8178, (Mouse) 13716
in utero embryonic development
transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
positive regulation of transcription elongation from RNA polymerase II promoter
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
positive regulation of transcription from RNA polymerase III promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of phosphatase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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