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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:100 | - |
Flow Cytometry (Flow) |
1:10-1:50 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human |
Host/Isotype |
Rabbit / Ig |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide between 32-58 amino acids from the N-terminal region of human ELOVL6 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2 mg/mL |
Purification |
Ammonium sulfate precipitation, Size-exclusion - Dialysis |
Storage buffer |
PBS |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2246590 |
This antibody is predicted to react with chicken and rat based on sequence homology.
Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3-keto acyl-CoA synthase ELOVL6; Elongation of very long chain fatty acids protein 6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast); ELOVL fatty acid elongase 6; Fatty acid elongase 2; Fatty acyl-CoA elongase; hELO2; Long chain fatty acid elongase; long chain fatty acyl elongase; Long-chain fatty-acyl elongase; Myelin-associated SUR4 protein; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6; very-long-chain 3-oxoacyl-CoA synthase 6
Gene Aliases: C77826; ELOVL6; FACE; FAE; LCE; Masr
UniProt ID: (Human) Q9H5J4, (Mouse) Q920L5
Entrez Gene ID: (Human) 79071, (Mouse) 170439
Molecular Function:
acyltransferase
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