Immunogen sequence: AELPPVPGGP RGPGELAKYG LPGLAQLKSR ESYVLCYDPR TRGALWVVEQ LRPERLRGDG DRRECDFRED DSVHAYHRAT NADYRGSGFD RGHLAAAANH RWSQKAMDDT FYLSNVAPQV PHLNQNAWNN LEKYSRSLTR SYQNVYVCTG PLFLPRTEAD GKSYVKYQVI GKNHVAVPTH FFKVLILEAA GGQIELRTYV MPNAPVDEAI PLERFLVPIE SIERASGLLF VPNILARAGS LKAITAGSK; Positive Samples: HeLa, MCF7, SW620, Mouse heart, Mouse kidney, Rat heart; Cellular Location: Mitochondrion
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
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Protein Aliases: Endo G; Endonuclease G, mitochondrial; mitochondrial endonuclease G
Gene Aliases: ENDOG