This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: QHLIIFDYIS VSASLENRVC EYVDHLHEHF KYPVMIQRAS YMPPKDPGYS TEMKEESVKK HQYPDGEVWK K
Highest antigen sequence identity to the following orthologs: Mouse - 26%, Rat - 25%.
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antisense RNA to thymidylate synthase; HSRTSBETA; L-fuconate dehydratase; Mitochondrial enolase superfamily member 1; rTS; rTS alpha; rTS beta; TYMSAS
Gene Aliases: ENOSF1; RTS; TYMSAS
UniProt ID: (Human) Q7L5Y1
Entrez Gene ID: (Human) 55556