This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants.
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Protein Aliases: APK1 antigen; Cytosolic ovarian carcinoma antigen 1; Ecto-NOX disulfide-thiol exchanger 2; Hydroquinone [NADH] oxidase; Protein disulfide-thiol oxidoreductase; tNOX; Tumor-associated hydroquinone oxidase
Gene Aliases: APK1; COVA1; ENOX2; tNOX