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Invitrogen
ENPP1 Polyclonal Antibody
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ENPP1 Antibody (PA5-119090) in IHC (P)
Immunohistochemistry analysis of ENPP1 in paraffin-embedded Rat Intestine tissue. Samples were incubated with polyclonal antibody (Product # PA5-119090) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-119090
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Ectonucleotide Pyrophosphatase/Phosphodiesterase 1. The antigen corresponds to amino acid range 568-793 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2903590
Target Information
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1
Gene Aliases: Enpp1; Npps; Pc1; Pdnp1
UniProt ID: (Rat) Q924C3
Entrez Gene ID: (Rat) 85496
molecular_function
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
scavenger receptor activity
insulin receptor binding
calcium ion binding
ATP binding
zinc ion binding
polysaccharide binding
NADH pyrophosphatase activity
protein homodimerization activity
metal ion binding
nucleoside-triphosphate diphosphatase activity
generation of precursor metabolites and energy
phosphate-containing compound metabolic process
receptor-mediated endocytosis
immune response
biological_process
nucleoside triphosphate catabolic process
negative regulation of ossification
negative regulation of cell growth
inorganic diphosphate transport
cellular phosphate ion homeostasis
sequestering of triglyceride
biomineral tissue development
negative regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of fat cell differentiation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
bone remodeling
3'-phosphoadenosine 5'-phosphosulfate metabolic process
nucleic acid phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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