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Invitrogen
ENPP1 Polyclonal Antibody
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Product Details
PA5-17097
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Leu520 of human ENPP1
Conjugate
Form
Liquid
Concentration
162 µg/mL
Amount
16.2 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41 antigen; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1; unnamed protein product
Gene Aliases: ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PC1; PCA1; PDNP1
UniProt ID: (Human) P22413, (Rat) Q924C3
Entrez Gene ID: (Human) 5167, (Rat) 85496
nucleic acid binding
3',5'-cyclic-AMP phosphodiesterase activity
exonuclease activity
phosphodiesterase I activity
nucleotide diphosphatase activity
scavenger receptor activity
insulin receptor binding
calcium ion binding
protein binding
ATP binding
zinc ion binding
hydrolase activity
phosphatase activity
polysaccharide binding
GTP diphosphatase activity
UTP diphosphatase activity
protein homodimerization activity
metal ion binding
nucleoside-triphosphate diphosphatase activity
ATP diphosphatase activity
3'-phosphoadenosine 5'-phosphosulfate binding
cyclic-GMP-AMP hydrolase activity
molecular_function
NADH pyrophosphatase activity
generation of precursor metabolites and energy
phosphate-containing compound metabolic process
receptor-mediated endocytosis
immune response
biological_process
nucleoside triphosphate catabolic process
negative regulation of ossification
negative regulation of cell growth
inorganic diphosphate transport
cellular phosphate ion homeostasis
sequestering of triglyceride
biomineral tissue development
negative regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of fat cell differentiation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
bone remodeling
3'-phosphoadenosine 5'-phosphosulfate metabolic process
nucleic acid phosphodiester bond hydrolysis
gene expression
vesicle-mediated transport
bone mineralization
melanocyte differentiation
regulation of bone mineralization
negative regulation of bone mineralization
response to ATP
ATP metabolic process
animal organ development
phosphate ion homeostasis
nucleic acid metabolic process
negative regulation of hh target transcription factor activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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