Keep as concentrated solution.
Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (87%), Chicken (95%), Bovine (95%).
Positive Control: human cerebrospinal fluid.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Autotaxin; autotaxin-t; AutotaxinATX; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
Gene Aliases: ATX; ATX-X; AUTOTAXIN; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2
UniProt ID: (Human) Q13822
Entrez Gene ID: (Human) 5168