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Immunogen sequence: VKMSSGGEK VVLKPNDVSV FMTLTINGRL FACPREQFDS LTPLPEQEGP TVGTVGTFEL MSSKDLAYQM TIYDWELFNC VHELELIYHT FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM DPSRNHRAYR LTVAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS QMSHRLEPRR P (712-1011 aa encoded by BC024004)
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; EPAC 2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; gefii; putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; RAP guanine-nucleotide-exchange factor (GEF) 4
Gene Aliases: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; CAMP-GEFII; CAMPS; CGEF2; EPAC; EPAC 2; Epac-2; EPAC2; mKIAA4040; Nbla00496; RAPGEF4
Molecular Function: guanyl-nucleotide exchange factor