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Invitrogen
ERCC1 Polyclonal Antibody
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Product Details
PA5-70171
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human ERCC1 (aa 191-240)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Yeast: 93%; Zebrafish: 93%
Target Information
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA excision repair protein ERCC-1
Gene Aliases: Ercc-1; Ercc1
UniProt ID: (Mouse) P07903
Entrez Gene ID: (Mouse) 13870
single-stranded DNA endodeoxyribonuclease activity
TFIID-class transcription factor binding
DNA binding
damaged DNA binding
single-stranded DNA binding
nuclease activity
endonuclease activity
protein binding
protein C-terminus binding
hydrolase activity
TBP-class protein binding
protein domain specific binding
structure-specific DNA binding
endodeoxyribonuclease
pyrimidine dimer repair by nucleotide-excision repair
replicative cell aging
DNA repair
nucleotide-excision repair
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
DNA recombination
mitotic recombination
syncytium formation
cellular response to DNA damage stimulus
response to oxidative stress
germ cell development
spermatogenesis
cell proliferation
male gonad development
UV protection
response to X-ray
multicellular organism aging
negative regulation of telomere maintenance
post-embryonic hemopoiesis
multicellular organism growth
interstrand cross-link repair
isotype switching
cell development
oogenesis
chromosome organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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