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Product Details
PA5-21281
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 194 of CSA (Uniprot ID#Q13216)
Conjugate
Unconjugated
Form
Liquid
Concentration
5.39 mg/mL
Purification
Protein A
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11153738
Product Specific Information
Recommended positive controls: Molt-4, C8D30, Rat2.
Predicted reactivity: Mouse (91%), Rat (91%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cockayne syndrome 1 (classical); Cockayne syndrome 1 homolog; Cockayne syndrome WD repeat protein CSA; Cockayne syndrome WD repeat protein CSA homolog; Cockayne syndrome WD-repeat protein CSA; DNA excision repair protein ERCC-8; excision repair cross-complementation group 8; excision repair cross-complementing rodent repair deficiency complementation group 8; excision repair cross-complementing rodent repair deficiency, complementation group 8; excision repaiross-complementing rodent repair deficiency, complementation group 8
Gene Aliases: 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; CKN1; CSA; ERCC8; UVSS2
UniProt ID: (Human) Q13216, (Mouse) Q8CFD5
Entrez Gene ID: (Human) 1161, (Rat) 310071, (Mouse) 71991
Molecular Function:
DNA metabolism protein
nucleic acid metabolism protein
protein polyubiquitination
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
cellular response to DNA damage stimulus
response to oxidative stress
response to UV
response to X-ray
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
biological_process
positive regulation of DNA repair
DNA repair
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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