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Proteintech
ERLIN2 Polyclonal Antibody
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Product Details
14781-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ERLIN2 Fusion Protein Ag6369 (23-206 aa encoded by BC067765)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VHKIEEGHI GVYYRGGALL TSTSGPGFHL MLPFITSYKS VQTTLQTDEV KNVPCGTSGG VMIYFDRIEV VNFLVPNAVY DIVKNYTADY DKALIFNKIH HELNQFCSVH TLQEVYIELF GKKVSPEHAV LKQGSWNPAS LHCLKPGCLQ GVMVTYGQEM LKNLVLRSWS QRSSWRMLIA MQQDP (23-206 aa encoded by B C067765)
Target Information
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250|UniProtKB:Q8BFZ9, ECO:0000312|EMBL:AAI68668.1}; epididymis secretory sperm binding protein; Erlin-2; erlin-2 {ECO:0000250|UniProtKB:Q8BFZ9}; erlin2 {ECO:0000312|EMBL:AAI68668.1, ECO:0000312|RGD:1309010}; HGNC:1356; MGC87072; spastic paraplegia 18 (autosomal dominant); SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250|UniProtKB:Q8BFZ9, ECO:0000312|EMBL:AAI68668.1}; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250|UniProtKB:Q8BFZ9}; unnamed protein product; UNQ2441
Gene Aliases: BC036333; C87251; C8orf2; Erlin-2; ERLIN2; NET32; RGD1309010; SPFH2; SPG18; SPG18A; SPG18B; UNQ2441/PRO5003/PRO9924
UniProt ID: (Human) O94905, (Mouse) Q8BFZ9, (Rat) B5DEH2
Entrez Gene ID: (Human) 11160, (Mouse) 244373, (Rat) 290823
lipid metabolic process
steroid metabolic process
cholesterol metabolic process
SREBP signaling pathway
ERAD pathway
regulation of cholesterol biosynthetic process
negative regulation of cholesterol biosynthetic process
negative regulation of fatty acid biosynthetic process
ER-associated ubiquitin-dependent protein catabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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