Proteintech

ERO1LB Polyclonal Antibody

ERO1LB Antibody in Immunocytochemistry (ICC/IF)

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ERO1LB Antibody (11261-2-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 11261-2-AP (ERO1LB antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ERO1LB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11261-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ERO1LB Fusion Protein Ag1776 (166-467 aa encoded by BC032823)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ELDDERSPA AQYVDLLLNP ERYTGYKGTS AWRVWNSIYE ENCFKPRSVY RPLNPLAPSR GEDDGESFYT WLEGLCLEKR VFYKLISGLH ASINLHLCAN YLLEETWGKP SWGPNIKEFK HRFDPVETKG EGPRRLKNLY FLYLIELRAL SKVAPYFERS IVDLYTGNAE EDADTKTLLL NIFQDTKSFP MHFDEKSMFA GDKKGAKSLK EEFRLHFKNI SRIMDCVGCD KCRLWGKLQT QGLGTALKIL FSEKEIQKLP ENSPSKGFQL TRQEIVALLN AFGRLSTSIR DLQNFKVLLQ HSR (166-467 aa encoded by BC032823)

Target Information

ERO1LB is essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. ERO1LB acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. ERO1LB does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification of Natural Product Sulfuretin Derivatives as Inhibitors for the Endoplasmic Reticulum Redox Protein ERO1α.

ACS bio & med chem Au

Johnson BD,Kaulagari S,Chen WC,Hayes K,Geldenhuys WJ,Hazlehurst LA

Wed Apr 20 00:00:00 UTC 2022

Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cells.

Scientific reports

Takei N,Yoneda A,Sakai-Sawada K,Kosaka M,Minomi K,Tamura Y

Thu Aug 24 00:00:00 UTC 2017

Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cells.

Scientific reports

Takei N,Yoneda A,Sakai-Sawada K,Kosaka M,Minomi K,Tamura Y

Thu Aug 24 00:00:00 UTC 2017

Curcumin facilitates a transitory cellular stress response in Trembler-J mice.

Human molecular genetics

Okamoto Y,Pehlivan D,Wiszniewski W,Beck CR,Snipes GJ,Lupski JR,Khajavi M

Sun Dec 01 00:00:00 UTC 2013

Curcumin facilitates a transitory cellular stress response in Trembler-J mice.

Human molecular genetics

Okamoto Y,Pehlivan D,Wiszniewski W,Beck CR,Snipes GJ,Lupski JR,Khajavi M

Sun Dec 01 00:00:00 UTC 2013

Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

The Journal of biological chemistry

Rajpal G,Schuiki I,Liu M,Volchuk A,Arvan P

Mon Jan 02 00:00:00 UTC 2012

Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

The Journal of biological chemistry

Rajpal G,Schuiki I,Liu M,Volchuk A,Arvan P

Mon Jan 02 00:00:00 UTC 2012

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Journal of toxicology

Galligan JJ,Smathers RL,Shearn CT,Fritz KS,Backos DS,Jiang H,Franklin CC,Orlicky DJ,Maclean KN,Petersen DR

Thu Aug 23 00:00:00 UTC 2012

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Journal of toxicology

Galligan JJ,Smathers RL,Shearn CT,Fritz KS,Backos DS,Jiang H,Franklin CC,Orlicky DJ,Maclean KN,Petersen DR

Thu Aug 23 00:00:00 UTC 2012

Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.

Endocrinology

Khoo C,Yang J,Rajpal G,Wang Y,Liu J,Arvan P,Stoffers DA

Fri Jul 01 00:00:00 UTC 2011

Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.

Endocrinology

Khoo C,Yang J,Rajpal G,Wang Y,Liu J,Arvan P,Stoffers DA

Fri Jul 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: endoplasmic oxidoreductase 1 beta; endoplasmic oxidoreductin-1-like protein B; Endoplasmic reticulum oxidoreductase beta; Endoplasmic reticulum oxidoreductin-1-like protein B; ERO1-L-beta; ERO1-like beta; ERO1-like protein beta; Oxidoreductin-1-L-beta

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Gene Aliases: 1300013B24Rik; 1700065B09Rik; AI447560; ero1-beta; ERO1B; Ero1beta; ERO1LB; RGD1563548

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UniProt ID: (Human) Q86YB8, (Mouse) Q8R2E9

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Entrez Gene ID: (Human) 56605, (Mouse) 67475, (Rat) 364755

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Function(s)

protein disulfide isomerase activity protein binding protein disulfide oxidoreductase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor unfolded protein binding peptide-methionine (S)-S-oxide reductase activity peptide-methionine (R)-S-oxide reductase activity methionine-R-sulfoxide reductase activity oxidoreductase

Process(es)

protein folding 4-hydroxyproline metabolic process protein maturation by protein folding insulin processing extracellular matrix organization glucose homeostasis cell redox homeostasis oxidation-reduction process transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ERO1LB Polyclonal Antibody

ERO1LB Antibody (11261-2-AP) in ICC/IF

Product Details

11261-2-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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