This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
PA3-009 detects ERp57 protein in human samples.
PA3-009 has successfully been used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a 57 kDa protein representing ERp57 in rat liver homogenate.
The PA3-009 immunogen is a synthetic peptide corresponding to residues I(490) Q E E K P K K K K K A Q E D L(505) of human ERp57. This peptide (Cat. # PEP-225) is available for use in neutralization and control experiments.
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; epididymis secretory protein Li 269; epididymis secretory sperm binding protein Li 93n; ER p57; ER protein 57; ER protein 60; ERp 57; glucose regulated protein, 58kDa; GRP 57; GRP 58; p58; PDIA 3; phospholipase C-alpha; PI PLC; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3
Gene Aliases: ER60; ERP57; ERP60; ERp61; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; PDIA3; PI-PLC
UniProt ID: (Human) Q8IYF8
Entrez Gene ID: (Human) 2923
Molecular Function: chaperone