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Invitrogen
ESRRG Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
ESRRG Antibody (PA5-27755) in WB
Western blot was performed using Anti-ESRRG Polyclonal Antibody (Product # PA5-27755) and a ~57 kDa band corresponding to Estrogen-related receptor gamma was observed across cell lines and tissues tested. Nuclear enriched extracts (30 µg lysate) of SH-SY5Y (Lane 1), SH-SY5Y treated with Retinoic Acid (Lane 2) and Mouse Brain (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (... View More
Product Details
PA5-27755
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment contain a sequence corresponding to a region within amino acids 53 and 435 of ERR gamma
Conjugate
Form
Liquid
Concentration
1.55 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545231
Product Specific Information
Recommended positive controls: A431, mouse brain, rat spleen.
Predicted reactivity: Mouse (100%), Rat (100%), Chicken (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Estrogen-related receptor gamma (ERRG, ERR3, NR3B3) is an orphan member of the nuclear hormone receptor superfamily. ERRG acts as a transcription activator in the absence of a bound ligand. It binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. ERRG also induces the expression of PERM1 in the skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781L1617; ERR gamma; ERR gamma-2; Estrogen receptor-related protein 3; estrogen-related receptor 3; Estrogen-related receptor gamma; FLJ16023; Nuclear receptor subfamily 3 group B member 3
Gene Aliases: ERR3; Errg; ERRG2; ERRgamma; ESRRG; KIAA0832; mKIAA0832; NR3B3
UniProt ID: (Human) P62508, (Mouse) P62509, (Rat) P62510
Entrez Gene ID: (Human) 2104, (Mouse) 26381, (Rat) 360896
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
steroid hormone receptor activity
retinoic acid receptor activity
steroid binding
protein binding
zinc ion binding
AF-2 domain binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
calmodulin binding
sequence-specific DNA binding
metal ion binding
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
intracellular receptor signaling pathway
steroid hormone mediated signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
transcription initiation from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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