Peptide sequence: PDNQRPLLKT DMERHINEED TVPLSHFDES MAYMPEGGCC NPHPYNEGYV
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Zebrafish: 86%
ETV1: ets variant gene 1. Several members of the Ets gene family encode sequence-specific DNA binding proteins that recognize DNA sequences with a centrally located 5'-GGAA-3' element. All of the Ets proteins recognize the same central core sequence but each protein interacts with unique sequences that flank this core. ER81 (also designated ETV1) binds the motif 5'-CGGAA/T-3'. ER81 is highly expressed in brain, testis, lung and heart. ER81 is also moderately expressed in spleen, pancreas, colon and small intestine. During development, ER81 displays a unique expression patterns which suggests that this transcriptional factor might play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity while MAPKAP kinase 2 inhibits ER81.
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Protein Aliases: DKFZp781L0674; ER81; ets related protein 81; ETS transcription factor Er81; ETS translocation variant 1; Ets variant 1; ets variant gene 1; ets variant gene 1-like; Ets-related protein 81; MGC104699; MGC120533; MGC120534
Gene Aliases: BOS_4062; ER81; Etsrp81; ETV1