Immunogen sequence: ASQSFPPPLMI KQEPRDFAYD SEVPSCHSIY MRQEGFLAHP SRTEGCMFEK GPRQFYDDTC VVPE
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 98%.
ETV1: ets variant gene 1. Several members of the Ets gene family encode sequence-specific DNA binding proteins that recognize DNA sequences with a centrally located 5'-GGAA-3' element. All of the Ets proteins recognize the same central core sequence but each protein interacts with unique sequences that flank this core. ER81 (also designated ETV1) binds the motif 5'-CGGAA/T-3'. ER81 is highly expressed in brain, testis, lung and heart. ER81 is also moderately expressed in spleen, pancreas, colon and small intestine. During development, ER81 displays a unique expression patterns which suggests that this transcriptional factor might play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity while MAPKAP kinase 2 inhibits ER81.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp781L0674; ER81; ETS translocation variant 1; Ets variant 1; ets variant gene 1; Ets-related protein 81; MGC104699; MGC120533; MGC120534
Gene Aliases: ER81; ETV1
UniProt ID: (Human) P50549
Entrez Gene ID: (Human) 2115