Peptide sequence: MLDLDNDTRP SVLGHLSQTA SLKRGSSFQS GRDDTWRYKT PHRVAFVEKL
Sequence homology: Cow: 85%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.
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Protein Aliases: Exocyst complex component 2; Exocyst complex component Sec5; SEC5-like 1
Gene Aliases: EXOC2; SEC5; SEC5L1; Sec5p
UniProt ID: (Human) Q96KP1
Entrez Gene ID: (Human) 55770